Ion Chromatography Standards
Apexbio Technology LLC Hematoxylin 517-28-2 1g
Hematoxylin (CAS 517-28-2) is a naturally derived dye obtained from the heartwood of Haematoxylum campechianum Upon oxidation hematoxylin forms a quinone structure that complexes with metal ions such as aluminum or iron producing a cationic dye-metal complex This complex preferentially binds to basophilic cellular components particularly nucleic acids within cell nuclei resulting in prominent nuclear staining Hematoxylin is most commonly applied in combination with eosin in H E staining protocols facilitating differentiation of nuclear and cytoplasmic structures in histological and pathological tissue analysis
Apexbio Technology LLC EDTA 60-00-4 1g
EDTA (60-00-4) is a chelating agent targeting polyvalent metal ions such as calcium magnesium and iron It is designed to sequester metal ion cofactors thereby inhibiting metal-dependent enzymatic reactions and stabilizing proteins EDTA exerts its biological activity primarily through the formation of stable coordination complexes with metal ions preventing their participation in biochemical processes In biochemical and cell culture studies EDTA demonstrates inhibition of metal-dependent enzymes and preservation of reagent stability Based on these pharmacological properties EDTA holds research potential in protein purification nucleic acid isolation enzyme assays chromatography coronary artery disease and neurological disease studies
Apexbio Technology LLC Nikethamide 59-26-7 1g
Nikethamide is a small-molecule respiratory stimulant designed to modulate the respiratory center in the medulla oblongata thereby regulating central respiratory sensitivity Nikethamide exerts its biological activity primarily through modulation of neural pathways within the central nervous system potentially involving nicotinic receptors and neurotransmitter signaling cascades Based on these pharmacological properties Nikethamide holds research potential in investigating respiratory dysfunction respiratory failure and the signaling mechanisms governing respiratory neural control
Apexbio Technology LLC Cromolyn sodium 15826-37-6 1g
Cromolyn sodium (CAS 15826-37-6) is a small molecule that functions as a mast cell membrane stabilizer It inhibits antigen-induced histamine release by preventing degranulation of sensitized mast cells Due to minimal gastrointestinal absorption cromolyn sodium is typically administered via inhalation in powder form Preclinical studies have demonstrated that cromolyn sodium suppresses both immediate and late-phase asthmatic responses and reduces the release of non-histamine chemical mediators Additionally it prevents ciliary transport impairment associated with bronchial provocation and can mitigate symptoms in exercise-induced asthma models These properties make cromolyn sodium a useful tool for investigating allergic and inflammatory mechanisms in respiratory research
Apexbio Technology LLC Enoxolone 471-53-4 1g
Enoxolone (CAS 471-53-4) also known as glycyrrhetinic acid is a principal component of licorice with reported antiviral and antifungal activities It modulates corticosteroid signaling by inhibiting 11 -hydroxysteroid dehydrogenase (11 -HSD) isoenzymes in hepatic and renal tissues In rats the IC50 values for 18 -enoxolone-mediated inhibition of 11 -HSD activity are 0 09 M in liver and 0 36 M in kidney homogenates Enoxolone also suppresses 11 -HSD activity in human JEG-3 choriocarcinoma cells This compound is used in biomedical research to study glucocorticoid metabolism mineralocorticoid receptor specificity and enzyme regulation in steroidogenesis
Apexbio Technology LLC Cephalexin monohydrate 23325-78-2 1g
Cephalexin monohydrate (CAS 23325-78-2) is a small-molecule inhibitor targeting penicillin-binding proteins (PBPs) It is designed to inhibit PBPs thereby impairing bacterial cell wall synthesis and compromising cell wall integrity Cephalexin monohydrate exerts its biological activity primarily through disruption of bacterial cell wall cross-linking leading to cell lysis In in vitro studies cephalexin monohydrate demonstrates inhibitory activity with reported MIC values ranging from 0 5 g/mL to 32 g/mL depending on bacterial species and experimental conditions IC50 values are dependent upon specific bacterial strains evaluated Based on these pharmacological properties cephalexin monohydrate holds research potential in antimicrobial susceptibility testing bacterial resistance studies and related microbiological assays
Apexbio Technology LLC Spermine 71-44-3 1g
Spermine (71-44-3) is a small-molecule inhibitor targeting inward rectifier potassium (K ) channels It is designed to block channel conductance thereby modulating cellular excitability and resting membrane potential Spermine exerts its biological activity primarily through direct inhibition of K channel function In experimental studies spermine demonstrates strong channel inhibition with an IC50 value of approximately 31 nM at a membrane potential of 50 mV in cloned IRK1 potassium channels Based on these pharmacological properties spermine holds research potential in potassium channel modulation neuronal excitability studies and investigation of neurological conditions associated with altered glutamatergic signaling and polyamine metabolism
Apexbio Technology LLC L-α-Aminoadipic Acid 1118-90-7 1g
L-alpha-Aminoadipic Acid (1118-90-7) is a small-molecule inhibitor targeting glutamine synthetase It is designed to competitively inhibit glutamine synthetase activity thereby modulating glutamate metabolism and neurotransmission pathways L-alpha-Aminoadipic Acid exerts its biological activity primarily through stereospecific competitive inhibition of glutamine synthetase In in vitro studies L-alpha-Aminoadipic Acid impacts astrocytic function preceding its gliotoxic effects and modulates kynurenic acid production in hippocampal tissues Based on these pharmacological properties L-alpha-Aminoadipic Acid holds research potential in the investigation of astrocyte function and neurological metabolism within neuroscience and pharmacology fields
Apexbio Technology LLC Rhodamine B 81-88-9 1g
Rhodamine B (81-88-9) is a synthetic fluorescent dye Its molecular structure enables excitation at specific wavelengths and emission of detectable fluorescence signals Rhodamine B is widely applied as a labeling agent in microscopy-based analyses facilitating visualization for intracellular labeling and tracking Researchers use Rhodamine B to stain cellular structures assess membrane permeability and monitor interactions of biomolecules such as proteins and nucleic acids Fluorescence intensity changes also support assays investigating enzyme activity apoptotic processes and intracellular uptake Based on these properties Rhodamine B holds research potential in cellular imaging biomolecular tracking and pharmaceutical distribution studies
Apexbio Technology LLC Oxymatrine 16837-52-8 1g
Oxymatrine (CAS 16837-52-8) is a quinolizidine alkaloid extracted from Sophora flavescens It has been shown to modulate multiple cellular pathways associated with fibrosis and neurodegeneration including inhibition of TGF- 1-mediated signaling and reduction of pro-inflammatory cytokine expression Oxymatrine exhibits antifibrotic and neuroprotective properties in various experimental models It is also extensively studied for its antiviral activity against hepatitis B virus and has been applied in traditional Chinese medicine for hepatitis management This compound is valuable for investigating mechanisms of fibrosis neuroprotection and viral pathogenesis
Apexbio Technology LLC Calcium Levofolinate 80433-71-2 1g
Calcium Levofolinate (CAS 80433-71-2) is the calcium salt of levoleucovorin the biologically active enantiomer of folinic acid It functions as a reduced folate cofactor bypassing dihydrofolate reductase inhibition to support DNA and RNA synthesis In biomedical research Calcium Levofolinate is used to modulate the effects of antifolate chemotherapeutic agents such as methotrexate reducing cytotoxicity in normal cells It is also investigated for its ability to enhance the cytotoxic activity of 5-fluorouracil through stabilization of the ternary complex with thymidylate synthase facilitating studies on nucleotide metabolism and chemotherapeutic mechanisms